thr77 login Options
thr77 login Options
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The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
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Overexpression of the gene has actually been observed in many tumors, which leads to chromosome instability, and so may possibly contribute to tumorigenesis. This protein was found to affiliate with, and be associated with, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in mobile-cycle regulated histone gene expression and plays a important part in advertising mobile-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of the gene, which encode distinct isoforms, are actually explained. Two extra splice variants were being documented but comprehensive nucleotide sequence information and facts just isn't yet readily available.
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Blocking peptides are peptides that bind particularly to your target antibody and block antibody binding. These peptide normally incorporates the epitope acknowledged because of the antibody.
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This guide outlines further probable optimization of mobile and immunoassay parameters to make certain the best possible success are...
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This guide outlines further attainable optimization of cellular and immunoassay parameters to make certain the absolute best benefits are...
Antibodies sure to the blocking peptide no more bind to your epitope over the goal protein. By comparing the staining in the blocked antibody versus check here the antibody alone, one can see which staining is particular.
Goal Details Cyclin E belongs for the highly conserved cyclin relatives, whose customers are characterised by a dramatic periodicity in protein abundance in the mobile cycle. Cyclins perform as regulators of CDK kinases. Distinct cyclins show distinct expression and degradation styles which add into the temporal coordination of each and every mitotic celebration. Cyclin E kinds a complex with and functions as being a regulatory subunit of CDK2, whose exercise is necessary for cell cycle G1/S transition. This protein accumulates in the G1-S section boundary and is particularly degraded as cells development by S stage.
The measurement of protein phosphorylation is a useful tool for measuring the modulation of receptor activation by both of those antibodies...
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